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The RSR Tg IRMA is used for reliable and quantitative determination of human thyroglobulin in serum. Tg is the precursor of thyroid hormones and therefore specific to the thyroid and thyroid derived tissue. Because of this, Tg determinations are important in the post-operative monitoring of differentiated thyroid carcinoma patients. Following total thyroidectomy and successful radioiodine treatment, Tg levels should fall to zero in patients who are free from metastases and tumour. A small quantity of Tg is continuously released into the serum of healthy individuals. However, in various non-malignant thyroid disorders, elevated levels are often observed, due to destruction or hyperactivity of thyroid follicles. These disorders include Hashimoto’s thyroiditis, hyperthyroid Graves’ disease and toxic nodular goitre.